Category: Immune Support

Immune support refers to vitamins, nutrients, and other supplements that can help keep your immune system healthy. A deficiency in certain nutrients can lead to poor immune function.

Immune support involves the lymphatic system, which is made up of organs and tissues that produce and store cells that fight off disease and infection. The lymphatic system includes:

Primary lymphoid organs: The thymus and bone marrow, where T and B cells develop and mature. The bone marrow creates all immune system cells from stem cells, including white blood cells, essential for immune responses.

Secondary lymphoid organs include the spleen, tonsils, lymph nodes, and specific tissue in mucous membranes, where B and T lymphocytes recognize foreign antigens and develop immune responses.

Other parts of the immune system include:

White blood cells are made in the bone marrow and move through the body’s blood and tissue, looking for foreign invaders like bacteria, viruses, parasites, and fungi. When they find invaders, they launch an immune attack.

Enzymes: These enzymes activate each other in a chain reaction that allows the immune response to multiply. Their tasks include:

Marking germs as targets for phagocytes.
Attracting other immune system cells.
Destroying bacteria cell walls.
Fighting viruses.

Some dietary supplements that may support the immune system include:

Vitamins A, C, D, and E
Minerals like selenium and zinc
Botanicals like Andrographis, echinacea, elderberry, garlic, and ginseng
Other ingredients like glutamine, N-acetylcysteine, glutathione, omega-3 fatty acids, and probiotics

Posted on July 6, 2024August 19, 2024 by CortControl

The Science Behind Glutrasol

How does Glutrasol Work?

To improve overall health and integrated treatment efficacy, Glutrasol supports the immune system by employing three chemistries key to Glutrasol’s science-based specialty supplement: transfer factor, beta-glucans, and lactic acid-generating bacteria.

Transfer Factor

Transfer factor is commonly derived from colostrum, a cow’s first milk after calf delivery. This milk contains information in the form of small proteins (polypeptides) that transfer immunity from cow to calf or from cow to human.

In Glutrasol, the proteins are separated by molecular weight. Other sources of transfer factors include eggs, sheep, goats, and lysed cells. As various sources are mixed, the scope of immunity typically increases. If people take transfer factors daily, their immune capability—as measured by killer white blood cells—could increase by as much as 250%.

Proteins are separated by molecular weight.

Beta-Glucan

Beta-glucan stimulates the two principal parts of the body’s immune system: the innate and the acquired immune systems.

Innate immune systems

In the innate immune system, beta-glucan binds with the macrophages, a white blood cell that detects bacteria, viruses, and other pathogens to coordinate the body’s defenses against them. When activated by beta-glucan, macrophages have a greater ability to identify and destroy foreign intruders. After devouring pathogens through phagocytosis, the macrophages communicate the intruder’s presence to the body’s other defenders. Research shows that macrophages fortified by beta-glucan can rally the body’s defenses.

Macrophage activation via cell surface receptor.

Acquired immune systems

After this, the acquired immune system joins the fight. With the information transmitted from the macrophages, the acquired immune system learns to manufacture other killer cells and blood factors designed to defend against a specific attack. These include B-cells, which produce antibodies. The antibodies, working with the innate immune system, destroy foreigners and bind them into clusters. Macrophages then overwhelm these. This process is how the body rids itself of infection and disease.

Lactic Acid-Generating Bacteria.

Lactic Acid-Generating Bacteria

Many assume that glucose is the primary energy source for living tissues, but there are indications that neurons in the human brain preferentially metabolize lactate, not glucose.

Digestive Health

Lactic acid-generating bacteria also have significant positive effects on digestive health. Foods such as cod liver oil and sauerkraut, for example, derive their benefit from lactic acid-generating bacteria. The liver, pancreas, and kidneys are less stressed with good digestion.

The immune system is supported because beneficial lactic acid-generating bacteria displace pathogens in the digestive tract, restoring healthy mucus in the intestinal lining.

Supporting Immune Health

—Richard Bennet, Ph.D.

An Integrative Approach to Supporting Immune Health

Glutrasol helps to support immune system health

The Challenge

The global need to address immunodeficiency disorders is real and immediate. Richard Bennet, Ph.D., states, “Our ability to create a really healthy immune system represents the greatest potential gains in health in the world.”

Immune System Health

The outcomes resulting from diminished immune system health are broad. Compromised immune health affects the ability to fight off pathogens, leaving at-risk populations, especially the elderly or 3rd world populations, at a deficit in avoiding disease.

At-Risk Populations

Seniors

Many seniors are at risk of contracting disease due to physical limitations, existing health concerns, or nutritional deficits. Providing a robust immune health foundation can effectively arm seniors with a better ability to maintain good health and vitality.

Developing Countries

In many developing countries, vast numbers of at-risk populations arrive at support organizations with immune systems that are severely compromised, either from inadequate nutrition, poor sanitation, environmental stress, or aging. Poor sanitation, nutritional food, and environmental distress are common and systemically complex to overcome.

One solution to support these at-risk groups is providing nutraceuticals or specialty supplements like Glutrasol to help these at-risk populations improve their immune system health.

Developing countries are located mainly in Africa, Asia, Latin America, and the Middle East.

Infectious disease epidemics cost the world US$60 billion each year. They match wars and natural disasters in their capacity to endanger lives, disrupt societies, and damage economies.

— Coalition for Epidemic Preparedness Innovations (CEPI)

Immune-System Health and Antigen Exposure

Immune system health is an important factor in fighting disease

Fighting Disease

Immune system health is an important factor in fighting disease. Dr. Ananya Mandal, MD, notes that “the reason for non-development of immunity to a disease could also be that the host’s immune system does not have a B cell capable of generating antibodies against the antigen or microbe or the immune system may not be strong enough to fight off the infection.”

Kenneth L. Marcella, DVM, states, “It is the immune system, after all, which allows humans and animals to recognize and remember potentially harmful foreign substances such as bacteria and viruses. The immune system allows us to respond to these threatening invaders in our systems.”

CortControl’s Glutrasol helps build the immune system to respond better to antigenic exposure.

Maximizing Immunity and Extended Protection

Glutrasol is a nutraceutical that was explicitly developed to support immune system health. When Glutrasol compounds were tested on cattle, cell-medicated immunity increased 4-5 times. Also, non-responsive populations to antigenic stimulus without Glutrasol compounds developed a response with Glutrasol compounds. Further, animal testing showed increased protection periods, making recipients less susceptible to additional health concerns.

Global healthcare workers treat huge populations in many developing countries.

Efficacy and extended protection periods affect logistics and economics. From a practical standpoint, reducing the frequency of interactions stretches the budget.

Fewer visits are required to achieve goals.
Delivery costs drop proportionately.
More time per visit becomes practical.
The need for follow-up treatments decreases.

Effective Delivery is Critical

“We should anticipate a growing frequency of infectious disease threats to global security,” says Peter Sands, Chair of the Commission on a Global Health Risk Framework for the Future. Maximizing the health of those in developing countries can help minimize the impacts of each new pandemic.

Treatments

Treatments must be stable and easy to manage in extreme climates and areas with significant sanitation challenges. Doses must be small, lightweight, and easy to administer and distribute.

Researchers

Researchers are looking at ways to enhance immune system health with easy-to-administer integrative solutions. Easy-to-transport specialty supplements are a promising approach. Glutrasol provides such a solution.

How Does Glutrasol Help Support Immune Health?

Glutrasol’s research shows:

An increased antibody titer for a subject by 4-5 times
Extended protection between vaccine booster treatments
Improved response to antigenic stimulus
Provides ease of delivery in hard-to-reach populations
The product is stable in scorching climates

Additional positive, proven outcomes from animal research

Reduced stress
Increased food utilization or growth rate
Improved off-spring mortality
Increased fertility

Supporting Fertility

An Integrative Approach to Supporting Fertility

Glutrasol helps to support fertility

The Challenge

Many people consider the prospect of having children one of life’s great experiences. Sadly, though, according to the Mayo Clinic, between 10% and 15% of all couples of childbearing age have difficulty either conceiving or carrying a pregnancy to term. The health of both men and women contributes to this statistic.

Immunity vs. Fertility

Contributors to fertility support are numerous. Among them are a healthy immune system and balanced cytokines.

The immune system and reproductive systems are interdependent. Reproductive immunology is a well-established field of medicine that studies interactions (or their absence) between the immune system and components related to the reproductive system.

Cytokines are critical components of the immune system.

They are small proteins that act as immunomodulating agents and impact immune response. The body’s immune resources are naturally prioritized to address health threats first. As a lesser priority, fertility capacity is negatively affected when the body inadequately fights pathogens—even at subclinical levels.

Cytokine Balance

Dr. Marie-Pierre Piccinni, Institute of Internal Medicine and Immunoallergology, University of Florence, Italy, determined that cytokine balance plays a significant role in implantation and successful pregnancy (Piccinni et al., 1998). Cytokine balances further allow the survival of the fetus throughout gestation. (Piccinni and Romagnani, 1996).

Further, a clinical study performed on 100 healthy women showed that a low FAAH (fatty acid amide hydrolase) activity in lymphocytes correlated with spontaneous abortion. [Source: Mauro Maccarrone, Department of Experimental Medicine and Biochemical Sciences and † Division of Obstetrics and Gynecology, University of Rome Tor Vergata, Rome, Italy; and ‡ Fatebenefratelli Association for Research, San Giovanni Calibita Hospital, Rome, Italy]

Fertility and Cytokine Balance

There are inflammatory and non-inflammatory cytokines

Women’s Fertility

The inflammatory-to-noninflammatory cytokine ratio is a known reliable indicator of women’s fertility. If the ratio is too high, conception is unlikely. If more balanced, the conception probability is higher. Pathogens interact with the immune system to create inflammatory cytokines. In contrast, friendly bacteria (such as lactic acid bacteria) create non-inflammatory cytokines.

Inflammatory Immune Cells

Inflammatory immune cells are drawn to a viral infection site by design. Once there, they produce their characteristic inflammatory cytokines. A robust immune system would soon rid the body of the virus, and the inflammatory cytokine level would fall. A weak immune system won’t finish the job, and high inflammatory cytokines will persist – even though viral symptoms may not be obvious.

One crucial factor, as relates to fertility, is to maintain the proper inflammatory-to-noninflammatory cytokine ratio.

Both Sexes Impacted

Cytokine balance can affect men and women in different ways.

A 2014 study published in the journal Seminars in Reproductive Medicine showed that inflammation can throw estrogen and progesterone, the two primary hormones involved in the menstruation cycle, out of whack. When these two hormones are out of balance, it’s nearly impossible to get pregnant or take a baby to full term.

Male fertility is also impacted. Anna Havrylyuk, Department of Clinical Immunology and Allergology, Danylo Halytsky Lviv National Medical University, Lviv, Ukraine, has noted that “Cytokines have been important mediators of immunity, and can be involved in numerous processes in the male genital tract, including acting as immunomodulatory elements within the male gonad.”

Stress, Immune Function and Fertility

Stress affects immune function, and immune function affects fertility.

Allen Morgan, MD, the director of the Shore Institute for Reproductive Medicine, says, “When stress-reduction techniques are employed, something happens in some women that allows them to get pregnant when they couldn’t get pregnant before.”

And, as Margareta D. Pisarska, MD, the co-director of the Center for Reproductive Medicine at the Cedars Sinai Medical Center in Los Angeles, has observed: “It’s becoming more and more important, in terms of what studies we do, to focus our efforts on the physiological effects of stress and how they may play a role in conception.”

The connection between immune function and stress is evident. When your body is stressed due to illness or emotional distress, it fights to get well. Reproduction is a lesser priority. At the University of California in San Diego, researchers found that highly stressed women ovulated 20% fewer eggs than women who experienced lower stress.

How Does Glutrasol Help Support Fertility?

Glutrasol strengthens the immune system with three active components: transfer factor, beta-glucans, and lactic acid-generating bacteria to support fertility. The combination contains and balances cytokines. Strengthened immunity leads to better health, and better health supports fertility.

Glutrasol offers a personalized, all-natural alternative for enhancing fertility

Glutrasol is a cost-effective fertility aid that is less costly, less invasive, and more effective than other claimed fertility aids. It can stand alone or augment an integrated program, providing a reliable and affordable solution. It offers a personalized, all-natural alternative for enhancing fertility.

To learn more, see Specialty Nutraceuticals and Fertility.

Supporting Endurance Athletic Performance

An Integrative Approach to Supporting Endurance Athletic Performance

Glutrasol helps support endurance athlete’s

The Challenge

Endurance athletes push through countless limits to compete in their sports. Most are rigorous and supremely disciplined regarding their nutrition, sleep, and training methods. However, many athletes may overlook immune system support as an integral component of their training, performance, and recovery regimen.

“When pursuing a more demanding training regimen, it’s important that the exerciser optimize immune responses,” writes Roy J. Shephard, M.D. Lond, PhD DPE, and Pang N. Shek, PhD of the University of Toronto School of Physical and Health Education.

Optimal Performance

The power of immune support is often misunderstood. Our immune system is usually primarily viewed as a matter of wellness versus illness rather than optimal performance. But it’s fundamental to both and is found to be compromised in many endurance athletes.

In fact, in the British Journal of Sports Medicine, Bente Klarlund Pedersen and Anders Dyhr Toft, from The Copenhagen Muscle Research Centre and Department of Infectious Diseases, note that “Moderate exercise across the lifespan seems to increase resistance to upper respiratory tract infections, whereas repeated strenuous exercise suppresses immune function.”

How the Immune System Affects Athletic Performance

The immune system is directly connected to the central nervous system via immune-system proteins (technically called “cytokines”). These proteins facilitate the release of regulating hormones, which mediate various everyday performance issues. We’ll examine some of the impacts of immune system imbalance regarding their implications for training, performance, and recovery.

Optimize Immune Responses

Demanding training regimens require a fast recovery

Before an Event

The value of a calm mind and sound sleep is well understood. Before an event, mental stress depletes energy reserves and reduces sleep quality.

Pre-event stress is cited as a negative factor in roughly 60% of competitors. Cortisol is the primary stress hormone. Mental stress effectively triggers the hypothalamus–pituitary–adrenal axis to produce cortisol. This sequence applies to all mammals.

Fortunately, the hypothalamus gland also houses the cortisol control loop. With the proper immune-protein stimulus from products like Glutrasol, cortisol production declines, sleep improves, and less vital energy is wasted.

During the Event

Changes in blood flow, increased cardiac output, heat dissipation, hydration status, and sweat production are critical factors during high-intensity exercise. These operating set points interact with each other and with the environment. Hormones (released in response to immune-protein permeation to the brain during exertion) affect the range of operation. Keeping these factors in a normal range is critical for peak performance.

Shephard and Shek further suggest that “participation in a major marathon event increased the odds of infection almost sixfold relative to the experience of other runners who did not participate.”

Performance and Recovery

Electrolyte losses are controlled by hormonal thermal regulation. Imbalances among water, sodium, potassium, and chloride limit performance. Willpower can’t substitute for electrolyte imbalance.

Likewise, elevated cortisol and catecholamine hormone levels, which increase during moderate and strenuous exercise, can negatively impact performance. Supporting healthy cortisol levels by balancing cytokine proteins associated with the immune system can have a positive
balancing effect.

As Katsuhiko Suzuki, Faculty of Sport Sciences, Waseda University, noted, “Cytokines mediate exercise-induced inflammation, immunosuppression, and energy metabolism.” Glutrasol enhances cytokine balance to support peak performance and recovery.

Recovery and Overtraining Syndrome (OTS)

Intense exercise stresses the body, and a fast recovery is necessary and a priority. We understand the importance of your recovery in maintaining peak performance.

“One of the major components of all training programs is the principle of progressive overload, implying working beyond a comfortable level,” write Joanna Ostapiuk-Karolczuk, Anna Kasperska, and Ryszard Botwina, of the University School of Physical Education, Poznan, Poland. “However, there is a fine line between improved performance and deterioration.”

Rebalance Faster

Without an adequate recovery, an athlete faces overtraining syndrome. Symptoms include respiratory infections, decreased serum testosterone, amenorrhea, impaired cognitive abilities, lack of concentration, and depression.

Recovery usually starts by replacing electrolytes (sodium, potassium, chloride, etc.) and water. At the finish line, everyone replenishes.

But that’s just the beginning. Recovery is primarily based on rebalancing the immune proteins, which balances the body’s hormones and stasis points. The body returns to its balanced condition, and Glutrasol enhances that balancing process so you can rebalance faster and be less susceptible to illness or overtraining injuries.

Support Before, During and After Competition:

Glutrasol will help you manage:

Optimal health during training
Stress before your endurance event
Optimal performance levels during your event
Increased recovery levels after your event

Glutrasol is a reliable choice for recovery enhancement. It is 100% natural and contains no WADA-banned substances. This natural composition reassures you that you’re fueling your body with the best without any concerns about doping.

To learn more, see Improve Your Athletic Ability.

Over 35 Years of Successful Treatments

Glutrasol testing has been conducted almost exclusively with animals at our sister company, Ramaekers Nutrition. For more than 40 years, veterinarians have prescribed many of the same compounds in Glutrasol to treat various diseases with considerable success.

Animal Testing

The animal testing range includes hundreds of thousands of cattle, pigs, horses, and other livestock, and the results have often been dramatic. Fertility in cattle, for example, has increased, in some cases, by more than 70%. In vaccine immuno-enhancement, Antibody Titers saw improvements of more than 360% at 21 days.

What is a Nutraceutical?

As a nutraceutical, Glutrasol is regulated as a dietary supplement by the FDA under the authority of the Federal Food, Drug, and Cosmetic Act. Unlike drugs, supplements are not intended to treat, diagnose, prevent, or cure diseases. A nutraceutical is a specialty supplement containing active constituents from foods, herbs, natural compounds, and other botanicals. Nutraceuticals have pharmacological benefits and are specially designed to support specific structure/function applications in the body.

More information on specialty supplements starts here: Specialty Supplements

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Posted on June 17, 2024August 22, 2024 by CortControl

Biochemistry of Transfer Factor: Technical Paper

Biochemistry of Transfer Factor. Female scientist looking under microscope doing analysis of test sample.

I. Introduction

Glutrasol and Transfer Factor Ultra products are comprised of three main ingredients:

Transfer Factor: A transfer factor is a chemical taken from a human or animal that has already developed protection (immunity) against a certain disease.
Glucans: A glucan is a polysaccharide derived from D-glucose, linked by glycosidic bonds. Glucans are noted in two forms: alpha-glucans and beta-glucans.
Lactic Acid-generating Bacteria: Lactic acid bacteria are a group of Gram-positive bacteria, non-respiring, non-spore-forming cocci or rods, that produce lactic acid as the primary end product of the fermentation of carbohydrates.

This disclosure focuses on the Biochemistry Transfer Factor.

Glutrasol and Transfer Factor Ultra work because TEST groups repeatedly show dramatic improvement relative to CONTROL groups.

Here is information on how (biochemically) they work.

II. Inducer/Suppressor Fraction of Transfer Factor

T-lymphocytes produce transfer factors and can transfer the ability to recognize a pathogen to cells that have not been in contact with the pathogen. They also heighten the immune system’s ability to react (increased reactivity or inducer function) to pathogens. Transfer factor produces a trigger for T-cell recognition of antigen.

The transfer factor is a mixture of peptides, typically with a molecular weight < 10,000 Daltons. It’s more appropriate to speak of “transfer factors” instead of “transfer factor.” Fortunately, today’s preparative methods produce consistent mixtures, which lead to repeatable responses.

Fractions within the mixture serve different (and sometimes opposite) purposes. Two significant fractions are (1) the inducer fraction and (2) the suppressor fraction^[1][2]. Opposing functions were confirmed using the direct Leucocyte Migration Inhibition (LMI) test.

These two fractions are consistent with field observations that the transfer factor balances the immune system.

For example:

The inducer fraction of transfer factor biochemistry links the immune cells with an antigen-binding site, thereby increasing their reactivity to an antigenic stimulus. This is advantageous when a higher immune response is required. CortControl’s enhanced vaccine response arises from an inducer fraction. Several researchers have documented the inducer effects of transfer factors^[3][4][5].
The suppressor fraction blocks the response of the T-cells and signals a down-regulation of the immune response. This is helpful in allergic or autoimmune conditions. Animal studies demonstrate improvement in cases where the immune system is over-active. This arises from suppressor fraction. Cortesini R. et al. ^[6] showed that CD8+CD28-Ts represent a unique subset of regulatory cells within the transfer factor that initiates a suppressive loop. Filaci ^[7] supported Cortesini’s work and related autoimmune diseases without CD8+ suppressor T lymphocytes. Filaci further found that “CD8+ Ts can be generated in vitro from CD8+CD28-T lymphocytes. A key role in their generation is played by monocytes that secrete interleukin-10 (IL-10) after granulocyte macrophage-colony-stimulating factor (GM-CSF) stimulation.”

Aleli Salazar-Ramiro et al. ^[8] view cancer as an autoimmune disease and propose a transfer factor for cancer therapy. This is supported by CortControl’s veterinary work on horses, dogs, and cows ^[9], where cancer symptoms were visibly reversed.

Immune Enhancement Dietary Supplement. Glutrasol™ offers humans therapeutic levels of transfer factors, glucans, prebiotics and probiotics, vitamins, and minerals, and has a rich vanilla flavor.

Glutrasol Dietary Supplement

Glutrasol offers therapeutic levels of transfer factors, glucans, prebiotics and probiotics, vitamins, and minerals and has a rich vanilla flavor.

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III. TH1/TH2 Helper Cells and Cytokines

Reviewing the helper lymphocyte paradigm helps categorize the transfer factor applications. Helper lymphocytes develop along two cell populations: TH1 and TH2. Transfer factors from both lymphocyte lines are represented in the transfer factor biochemistry. TH1 and TH2 cells perform different functions and produce different cytokines—proteins that function as messenger molecules.

Cell-mediated or TH1 helper responses are essential in the body’s ability to defend itself against viruses, fungi, parasites, cancer, and intracellular organisms. TH1 cells modulate cell-mediated immunity.

TH1 cells produce the following cytokines:

IL-2,
IFN-gamma, and
TNF-alpha

TH2 cells modulate humoral immunity (antibody production).

TH2 cells produce the following cytokines:

IL-4,
IL-5,
IL-6,
IL-10, and
IL-13

Cytokines are functionally similar to hormones but are not associated with a specific gland.

They appear to operate as keys and templates.

Cytokines are a broad and loose category of small proteins essential in cell signaling. Due to their size, cytokines cannot cross the lipid bilayer of cells to enter the cytoplasm and, therefore, typically exert their functions by interacting with specific cytokine receptors on the target cell surface.

Stereochemistry is important.

What is stereochemistry in simple terms?

A branch of chemistry that deals with the spatial arrangement of atoms and groups in molecules.
The spatial arrangement of atoms and groups in a compound and its relation to the properties of the compound.

The attachment of a cytokine to an immune cell receptor starts a specific immune signal within the target cell. Signals translate into direct action, increase the production of antibodies against an invading virus, or initiate the production of other cytokines to propagate the signal.

IV. TH1/TH2 Predominant Phenotypes

One aspect of immune regulation involves homeostasis between T-helper 1 (Th1) and T-helper 2 (Th2) activity ^[10]. TH1/TH2 balance correlates with good health, and over-activation in either direction sets the stage for disease.

Th1 and Th2-helper cells direct different immune response pathways and produce different cytokines. Either pathway can down-regulate the other.

Steven Bock, MD, correlated disease conditions to an imbalance of TH1 and TH2. For example, if one has a TH2-dominated condition, the disease conditions that tend to prevail are:

Allergies
Chronic sinusitis
Atopic eczema
Asthma
Systemic autoimmune conditions such as lupus erythematosus and mercury-induced autoimmunity
Vaccination-induced state
Certain cases of autism
Hyperinsulinism
Pertussis vaccination
Malaria
Helminth infection
Hepatitis C
Chronic giardiasis
Hypercortisolism
Chronic candidiasis
Cancer
Viral infections
Ulcerative colitis

If one has a TH1-dominated condition, the conditions that tend to prevail are:

Diabetes type 1
Multiple sclerosis
Rheumatoid arthritis
Uveitis
Crohn’s disease
Hashimoto’s disease
Sjögren’s syndrome
Psoriasis
Sarcoidosis
Chronic Lyme disease
H. pylori infections
E. histolytica

Glutrasol field observations show successes in both categories. For example, international travelers avoid flu and colds by consuming Glutrasol before a trip. In addition, Ramaekers Nutrition has success with psoriasis, Crohn’s disease, and H pylori infections (among a 20-year list of others). The biochemistry of transfer factor in Glutrasol contains cytokines from both TH1 and TH2 cells. It produces different cytokines for different situations.

Alvarez-Thull L, Kirkpatrick CH ^[11] note that “Transfer factor treatment selectively affects cytokine production in response to antigenic stimulation.”

Fabre RA et al. ^[12] (in a pulmonary tuberculosis study) showed that “the treatment with murine or human TF [transfer factor] restored the expression of TH-1 cytokines, TNFalpha and iNOS, provoking inhibition of bacterial proliferation and significant increase of DTH and survival.”

Transfer Factor Ultra

Transfer Factor Ultra ingredients are formulated at therapeutic levels for severe illness or as prevention for significant health challenges. As with any supplement, it is advisable to seek advice from your healthcare professional to ensure it suits you.

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V. Adjusting to Change

Malaria is cited as a TH2-dominated condition WHO ^[13] and PATH are working on a robust malaria vaccine.

CortControl acknowledges that parasites can mutate ^[14] and present a changing appearance to the immune system. This is one reason for the cyclical flare-ups experienced by malaria victims. Antibody vaccines are specific and not designed to keep pace with mutations.

Maturation time for TH1 or TH2 cells is 10-14 days. In contrast, the biochemistry of transfer factor works on the innate immune system and responds within 24-48 hours. Transfer factor empowers the immune system to stay current with mutations.

CortControl predicts that the immediate benefits of combining Glutrasol with malaria vaccine will be:

Increasing vaccine efficiency and
Minimizing relapse or re-infection.

VI. Rebalancing TH1 and TH2 Levels

Transfer factor can change TH1/TH2 predominance conditions within 48 hours ^[15].

This observation asks, “How can Transfer Factor change a predominantly TH-2 Immune System to a predominant TH-1 System so rapidly?”*

*The hypothesis of new TH1 cells was dismissed early because it takes 10-14 days to mature new TH1 cells.

The answer is “conversion by eomesodermin,” which was studied ^[16] in 2003.

Eomesodermin. Also known as T-box brain protein 2, is a protein encoded by the EOMES gene in humans. The Eomesodermin/Tbr2 gene, EOMES, encodes a member of a conserved protein family that shares a common DNA-binding domain, the T-box.

In that study, already-differentiated TH2 cells were converted to TH1 cells. Eomesodermin is a T-box transcription factor related to T-bet and is already characterized as a key regulator of mesodermal differentiation. Eomesodermin was up-regulated explicitly in activated CD8+ cells [one of the transfer factor’s actions].

The conversion of TH2 to TH1 cells applies to viral vaccines and malaria, which tend to be TH2-dominated. In the opposite direction, the conversion of TH1 to TH2 is advantageous for Rheumatoid arthritis or Crohn’s disease.

VII. Viruses, Bacteria, and Parasites

Web MD notes, “Transfer factors are used for infectious conditions in people with weak immune systems. These infectious conditions include bacteria or viruses in the bloodstream (septicemia), sinus infections, bronchitis, influenza, swine flu, the common cold, shingles, chickenpox, hepatitis B, fungal infections such as coccidioidomycosis, yeast infections (candidiasis), parasitic infections such as leishmaniasis and cryptosporidiosis, and leprosy.

Transfer factors are also used against infections caused by viruses such as cytomegalovirus (CMV) and Epstein-Barr virus, bacteria such as Mycobacterium tuberculosis, Mycobacterium fortuitum, and Mycobacterium avium, and yeast-like fungi such as Cryptococcus and Pneumocystis carinii.

The Glutrasol formulation dramatically lowered the mortality rate of parasite-infected livestock herds ^[9]. Simultaneously, weight gain improved.

CortControl does not believe that we “cured” the affected herds. Instead, we believe Glutrasol better staged the subject’s immune system to resist parasites and opportunistic infections.

This immune response has applications for countries where water-borne parasites negatively affect child development.

Stunted childhood growth is a significant global health issue. Low weight gain in livestock and stunted human growth are probably related.

VIII. Staging the Immune System

The response to vaccination depends on the recipient’s health. Vaccines work best for healthy people. Conversely, a person with a weakened immune system may not receive the calculated vaccine benefits. This relationship is significant in less developed countries, where unsanitary conditions impact overall health.

Dr Mandal ^[17] notes, “This [a lower-than-expected vaccine response] could be due to various reasons. Sometimes, this is because the host’s immune system doesn’t respond adequately or at all. This could be in diseased persons with lowered immunity, e.g., in people with diabetes, those on steroids or other immunity-suppressing drugs, or those with HIV infection.

B-Cell Activation. Once B cells are activated, they become plasma cells that produce antibodies in response to an antigen. They can also become memory cells that remember the antigen so the immune system can quickly identify and fight it in the future.

The non-development of immunity to disease could also be because the host’s immune system does not have a B cell capable of generating antibodies against the antigen or microbe or the immune system may not be strong enough to fight off the infection”.

Glutrasol. Formulated to narrow the health gap and make vaccine benefits accessible to a larger population.

IX. Adjuvant Application

Several articles suggest the use of the Transfer Factor as an adjuvant.

An adjuvant is a chemical substance added to some vaccines to help the body’s immune system respond more effectively to the vaccine’s antigens.

Schroder et al. ^[18] state, “This interspecies adjuvant effect was proportional to the dose of the ‘transfer-factor’ preparations administered, depended on the method of their preparation, and was expressed in the administration of the preparations simultaneously with the immunization.”

Wang et al. ^[19] state, “In conclusion, these results suggest that TF [transfer factor] possess better cellular immune-enhancing capability and would be exploited into an effective immune-adjuvant for inactivated vaccines.”

X. Dramatic Pictures of Results of Consuming Transfer Factor

The following images are two patient examples. We have an extensive database of animal results using our patented formulas.

Calf with Severe Warts

Before Transfer Factor Consumption

6 Months Later

After Transfer Factor Consumption

Horse with Eye Cancer

Before Transfer Factor Consumption

During Transfer Factor Consumption

After Transfer Factor Consumption

References

Lawrence HS, Borkowsky W., “Transfer factor—current status and future prospects,” Biotherapy 1996;9(1-3):1-5. https://www.ncbi.nlm.nih.gov/pubmed/8993750
www.linked2.info/dvm
Mazaheri R, Hamblin AS, Zuckerman AJ., “Cell-mediated immunity: correlation of mixed-leucocyte-macrophage migration inhibition with delayed-type hypersensitivity after immunization and donor-specific transfer of cell migration inhibition by dialyzable leucocyte extract,” Cell Immunol. 1983 Nov;82(1):147-62. https://www.ncbi.nlm.nih.gov/pubmed/6196129
Kirkpatrick CH, Rich RR, Smith TK., “Effect of transfer factor on lymphocyte function in anergic patients,” J Clin Invest, 1972 Nov;51(11):2948-58. https://www.ncbi.nlm.nih.gov/pubmed/5080419
Salazar-Ramiro A, Hernández-Pedro NY, Rangel-Lopez E, Cruz VPD, Estrada-Parra S, et al., “Dialyzable Leukocyte Extract (Transfer Factor) as Adjuvant Immunotherapy in the Treatment of Cancer,” MOJ Auto Dis 1(1): 00003. DOI: 10.15406/mojad.2016.01.00003.
Cortesini R1, LeMaoult J, Ciubotariu R, Cortesini NS., “CD8+CD28- T suppressor cells and the induction of antigen-specific, antigen-presenting cell-mediated suppression of Th reactivity”, Immunol Rev. 2001 Aug;182:201-6. https://www.ncbi.nlm.nih.gov/pubmed/11722635
Filaci G. et al., “Nonantigen specific CD8+ T suppressor lymphocytes originate from CD8+CD28- T cells and inhibit both T-cell proliferation and CTL function”, Hum Immunol. 2004 Feb;65(2):142-56. https://www.ncbi.nlm.nih.gov/pubmed/14969769
Salazar-Ramiro A, Hernández-Pedro NY, Rangel-Lopez E, Cruz VPD, Estrada-Parra S, et al., “Dialyzable Leukocyte Extract (Transfer Factor) as Adjuvant Immunotherapy in the Treatment of Cancer,” MOJ Auto Dis 1(1): 00003. DOI: 10.15406/mojad.2016.01.00003. http://medcraveonline.com/MOJAD/MOJAD-01-00003.php
http://ramaekersnutrition.com/library/the-mechanism-of-transfer-factor/
Kidd P., “Th1/Th2 balance: the hypothesis, its limitations, and implications for health and disease”, Altern Med Rev. 2003 Aug; 8(3):223-46. https://www.ncbi.nlm.nih.gov/pubmed/12946237
Kirkpatrick CH, Rich RR, Smith TK., “Effect of transfer factor on lymphocyte function in anergic patients,” J Clin Invest, 1972 Nov;51(11):2948-58. https://www.ncbi.nlm.nih.gov/pubmed/5080419
https://www.ncbi.nlm.nih.gov/pubmed/15086383
http://www.who.int/mediacentre/factsheets/fs094/en/ “Malaria Fact sheet N 94”. WHO. March 2014.
http://www.theexpandedheart.com/Transfer.html
http://ramaekersnutrition.com/library/the-mechanism-of-transfer-factor/
SCIENCE, p. 1041, Vol. 302, Nov. 2003. http://science.sciencemag.org/content/302/5647
http://www.news-medical.net/health/Vaccine-Effectiveness.aspx
https://www.ncbi.nlm.nih.gov/pubmed/419903
www.ncbi.nlm.nih.gov/pubmed/22705080

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Posted on June 11, 2024August 19, 2024 by CortControl

Specialty Nutraceuticals and Fertility

Supporting fertility in more people

For years, a significant barrier for couples seeking fertility support has been—purely and simply—cost. One recent University of California, San Francisco (UCSF) study revealed that couples seeking the popular treatment, in vitro fertilization (IVF), have an average out-of-pocket expense of $19,234.

In the U.S., this comes to an average of 44% of the annual disposable income for couples seeking treatment. “For many patients,” UCSF infertility specialist James F. Smith, MD, has noted, “the high costs … represent a significant burden on household finances and almost certainly have a major role in fertility treatment decision making.”

The specialty nutraceutical option

However, recent developments in specialty nutraceuticals may provide doctors and nutritionists with a valuable new option for offering their patients the solid first step in a comprehensive fertility support program.

These nutraceuticals also provide pharmaceutical companies focused on fertility support new opportunities to expand their product portfolios and their total available market. Considering the “significant” cost burden of traditional treatments for many couples and the chance to develop the total treatment market, the right nutraceutical is undoubtedly an option more doctors and pharmaceutical companies might want to investigate.

Specialty nutraceuticals and fertility treatment

Why specialty nutraceuticals?

While there is still some skepticism about specialty nutraceuticals, a growing body of evidence suggests that, as well as being far less costly than traditional fertility drugs and treatments, they may also be—in some instances—more effective.

To learn more, check out the Dietary Supplements Guidance Documents and Regulatory Information page on the FDA’s website.

CortControl’s specialty nutraceuticals

At CortControl, for example, we have a specialty nutraceutical called Glutrasol and Transfer Factor Ultra. For more than 20 years, veterinarians have prescribed many of its essential compounds to treat diseases and conditions in mammals, and the success of these treatments is well-documented and quite dramatic. In some cases, for example, fertility in cattle increased by more than 70%.

Glutrasol Dietary Supplement

Glutrasol offers therapeutic levels of transfer factors, glucans, prebiotics and probiotics, vitamins, and minerals and has a rich vanilla flavor.

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Why are we confident our supplements will make a difference in humans?

The answer is in science. All mammals, humans included, have essentially the exact cortisol production mechanism, and when the body produces too much cortisol, the chances of becoming infertile can increase in some instances.

Controlling cortisol production

Designed to control high cortisol production levels, Glutrasol and Transfer Factor Ultra—much like the compounds veterinarians have prescribed to cattle for years to increase fertility—should (and we believe will) have a similar effect on humans.

Cortisol Stress Hormone. Scale showing elevated stress level.

Cortisol is a stress hormone that can affect fertility in both men and women.

When women are stressed, the brain produces cortisol, which can disrupt the ovaries’ function and the release of eggs.

Hormonal balance: Cortisol can disrupt the hormonal balance needed to mature eggs. It can also decrease estradiol, which can damage egg quality.
Ovulation: Cortisol can disrupt signaling between the brain and ovaries, delaying or preventing ovulation.
Menstrual cycle: High levels of cortisol and prolactin can impair the menstrual cycle.
Blood flow: Cortisol can reduce blood flow to reproductive organs, like the ovaries.

Cortisol can also suppress reproductive hormones, leading to abnormal ovulation, anovulation, and amenorrhea.

Ovulation is when an ovary releases an egg that can be fertilized by sperm, potentially leading to pregnancy.
Anovulation, also known as an anovulatory cycle, is a medical condition that occurs when an egg is not released from the ovaries during a menstrual cycle.
Amenorrhea is when a woman who usually menstruates doesn’t have a period for three months or more if she’s had regular cycles or six months or more if she’s had at least one spontaneous period before.

The stress hormone cortisol affects fertility in men.

Cortisol can impact sperm production and motility in men. FSH, which is secreted by the anterior pituitary in response to GnRH, stimulates sperm production.

In men, Follicle-stimulating hormone (FSH) helps control the amount of sperm that the testicles (testes) make and affects the health of the sperm.
The gonadotropin-releasing hormone (GnRH) causes the testicles to produce testosterone.

Stress can also lead to behavioral changes that can impact fertility, such as decreased sex drive and motivation. While occasional stress may not affect fertility, chronic stress can lead to hormone imbalances that make it difficult to conceive.

What is the role of nutraceuticals in fertility?

Currently, nutraceuticals are a common and popular way to mitigate the male fertility issues of pre-testicular, testicular, and post-testicular etiologies.

Pre-testicular etiologies, also known as extra-gonadal endocrine disorders, are fertility issues that originate outside the reproductive system and prevent the testes from receiving adequate support. These disorders can affect spermatogenesis and originate in the hypothalamus, pituitary, or adrenals.
Testicular etiologies may derive from varicocele-induced testicular damage, undescended testes, testicular torsion, mumps orchitis, gonadotoxic effects from medications (including chemotherapy, radiation, and surgical resection), genetic abnormalities, and idiopathic causes (any disease that is of uncertain or unknown origin may be termed idiopathic).
Post-testicular etiologies are causes of infertility that occur after the testes and primarily involve obstructions in the ducts that lead away from the testes. These obstructions can occur anywhere in the male reproductive tract.

Nutraceuticals possess multi-nutritional factors that improve metabolic activity, regulating hormonal profile and sperm production.

Transfer Factor Ultra

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Nutrition plays a crucial role in fertility.

If you continuously supply your body with supplements, they can impact your metabolism, hormones, and entire endocrine system, which regulates fertility.

Eating a healthy, well-balanced diet and taking the proper supplements can improve fertility for both men and women.

Eating a healthy, will-balanced diet and taking the proper supplements can improve fertility for both men and women.

It is worth a close look

We are not claiming that specialty nutraceuticals such as Glutrasol and Transfer Factor Ultra are silver bullets. We are saying, however, that they offer promise in supporting fertility for a relatively low cost AND that they are worth considering as part of a comprehensive fertility support strategy—one that will ultimately enable more people to take advantage of infertility treatments.

A new approach to supporting fertility

Glutrasol and Transfer Factor Ultra are unique and patented science-based specialty supplements that offer a new approach to supporting fertility. They’re designed to address compromised immune function due to elevated stress, a factor that may contribute to an estimated 30% of all fertility problems in both women and men.

Consider enhancing your fertility with Glutrasol and Transfer Factor Ultra if you are:

Couples with fertility issues
Have known stressors that may be inhibiting fertility
Could benefit from minimizing the impact stress is having on your fertility
Looking for a natural, non-invasive, less costly fertility aid to enhance your ability to conceive

Specific positive outcomes include:

Significant increase in egg health
Increase in the number of healthy eggs
Increase in sperm count

CortControl develops, and markets patented specialty nutraceuticals

CortControl develops and markets Glutrasol and Transfer Factor Ultra. These patented specialty nutraceuticals support fertility, immune health, and other health concerns.

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Posted on June 5, 2024August 19, 2024 by CortControl

Medical Foods: As Patients Consider New Personalized Treatment Options, Health Care Providers Should Too

Like everything dynamic, healthcare treatment is evolving rapidly.

Today, more and more consumers are becoming intrigued by an approach to health care called “integrative medicine,” which offers new options—and opportunities—for improved personalized treatment for patients.

Furthermore, integrative medicine is not something radically new or different. The premise behind it is about as basic and sensible as ideas come. The thinking is that the best healthcare solutions might not necessarily be one-dimensional, as in “take this pill three times a day.” Instead, it might be a combination of drugs and complementary remedies such as diet, exercise, vitamins, and FDA-accepted specialty nutraceuticals.

What is a specialty nutraceutical?

Specialty nutraceuticals are dietary products explicitly developed to support specific structures or physical functions in the body. The term is a broad umbrella term used to describe any product derived from food sources that offers extra health benefits in addition to the basic nutritional value found in foods.

Of course, for some, the term “specialty nutraceutical” does not sound familiar, like “exercise” or “vitamins.” These nutraceuticals are still unfamiliar even to many doctors and others in health care.

Nutraceuticals are not substitutes for drugs and other traditional medical treatments but rather part of this integrative approach to safely and effectively support health issues.

Difference between a nutraceutical and a medicine

What is the difference between a nutraceutical and a medicine?

For one thing, pharmaceuticals are FDA-approved drugs designed to treat diseases and provide immediate relief. In contrast, nutraceuticals are nutrient-rich dietary substances derived from whole food or parts of food sources, offering health benefits beyond essential nutrition.

To learn more, check out the Dietary Supplements Guidance Documents and Regulatory Information page on the FDA’s website.

Doctors and pharmaceutical companies are slow to adapt

While interest in specialty nutraceuticals grows among consumers, many doctors and pharmaceutical companies resist them.

In one recent American Hospital Association survey, for example, 44% of respondents listed “physician resistance” as one of the three main barriers to adopting integrative medicine programs that may include specialty nutraceuticals in the mix.

Further barriers include some pharmaceutical companies. Instead of looking at nutraceuticals as an opportunity to serve their customers and pursue a potential revenue opportunity, they see specialty supplements as a threat to their businesses rather than a potential revenue opportunity to explore.

This pharma resistance is a shame because specialty nutraceuticals represent a promising new option for doctors and patients and a significant market opportunity for these companies.

It’s a slow process, but specialty nutraceutical markets are expected to grow in the next few years, providing patients with more solutions and treatment options.

Glutrasol Dietary Supplement

Glutrasol offers therapeutic levels of transfer factors, glucans, prebiotics and probiotics, vitamins, and minerals and has a rich vanilla flavor.

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Pharma, food, and nutraceuticals

Nutraceuticals are positioned between food and pharmaceuticals and are comprised of foods and substances—or combinations of substances—consisting of molecules or elements found in nature used to maintain or improve health and treat or prevent diseases and conditions.

To benefit consumers, pharmaceutical companies can:

Acknowledge the growing consumer interest in, and become advocates for, personalized treatment.
View specialty nutraceuticals as enhancements to their product lines and a clear competitive edge.
License patented, FDA-accepted specialty supplements to manufacture and distribute to their core markets. (Because these foods are already FDA-accepted, R&D costs are minimal, and time to market is rapid.)
Manufacture and offer products with substantial profit margins.
Help physicians and clinics improve their treatment protocols and better differentiate themselves.

Transfer Factor Ultra

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Personalized treatment is an idea whose time has come.

Medical foods are integral to this new standard, perspective, and set of ideas. This new paradigm is a new way for big pharma companies to reach customers and drive profits. Responding to this growing consumer demand makes sense for doctors who want to provide new patient options and pharmaceutical companies who want to strengthen their competitive edge.

Transfer Factor Ultra: CortControl Immune System Enhancement

If you’re looking for a dietary supplement that can help strengthen your immune system, Transfer Factor Ultra can be a viable option. This supplement contains Transfer Factor (TF), which helps educate and improve the immune system’s defense against harmful pathogens.

Glutrasol Dietary Supplement

Glutrasol provides an extra defense against the flu and other seasonal illnesses. It’s also excellent when traveling because it helps you avoid exposure to travel-related diseases. Gultrasol helps strengthen your overall immune health, especially if you are susceptible to disease or are elderly, not to mention if you spend time around many people, especially if they are sick.

CortControl develops, and markets patented specialty nutraceuticals

CortControl develops and markets Transfer Factor Ultra and Glutrasol. These patented specialty nutraceuticals support fertility, immune health, and other health concerns.

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Posted on May 15, 2024August 19, 2024 by CortControl

Improve Your Athletic Ability: 2024 Specialty Nutraceuticals

Improve Your Athletic Ability

Athletes, are you interested in performing at a higher level at your next athletic event? Are you looking for a better time, distance, more scored goals, or easier recovery after the event? We guess “absolutely” because sporting enjoyment and ability are two parts of the same package.

You may be an extreme athlete competing in every Ironman you can or an enthusiastic athlete who exercises hard but focuses more on physical enjoyment. Either way (extreme or energetic), modern athletes are learning that your immune system affects your athletic ability. The power of the immune system is not limited to wellness versus illness.

Extreme Athletes

If you are an extreme athlete, you understand first-hand the physical impacts of training, sleep, performance, and recovery. It’s not always pleasant.

Before an event, mental stress depletes energy reserves and reduces sleep quality. In turn, poor sleep detracts from performance. After an event, recovery takes time, and you are susceptible to getting sick for roughly five days.

Enthusiastic Athletes

If you are an enthusiastic athlete, your internal experience differs. Moderate levels of exercise are beneficial for the immune system. But your performance could be better.

Difference between extreme and enthusiastic athletes summarized

Bente Klarlund Pedersen and Anders Dyhr Toft (Copenhagen Muscle Research Centre and Department of Infectious Diseases) summarize this difference between extreme and enthusiastic athletes.

They state, “Moderate exercise across the lifespan seems to increase resistance to upper respiratory tract infections, whereas repeated strenuous exercise suppresses immune function.”*

*“Effects of exercise on lymphocytes and cytokines.”

The solution for extreme and enthusiastic athletes is to build and improve the immune system.

To start, here are some basics.

Your immune system has immune cells and immune proteins (technically called cytokines). Immune cells include macrophages (“big eaters”). As implied, the “big eaters” protect us by literally consuming viruses, fungi, and bacteria.
Immune proteins are the bosses of the immune system. They direct the action. Immune proteins work best when balanced. The imbalance isn’t good.
Immune proteins also connect the immune system to the central nervous system. These immune proteins facilitate the release of regulating hormones, which mediate various everyday performance issues.
Particularly important is that immune proteins can be increased and balanced.

Glutrasol Dietary Supplement

Glutrasol offers therapeutic levels of transfer factors, glucans, prebiotics and probiotics, vitamins, and minerals and has a rich vanilla flavor.

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Balancing the immune proteins is a powerful way to build the immune system.

Diet alone may not provide the immune proteins needed for balance. Enter Glutrasol. This performance supplement enhances immune protein balance in two ways.

First, balanced cytokines are injected directly into the digestive tract (where they are stable) and enter the body through the intestinal wall.

Second, even more balanced cytokines are produced within the body. That means that missing immune proteins are replaced.

Improve your athletic ability with specialty nutraceuticals.

Performance increases can be dramatic for all athletes because immune protein balance is restored. Energy levels increase, and a feeling of wellness arises.

Stamina replaces endurance. Motivation is easy when you feel good. For extreme athletes, recovery is fast, and respiratory infections are less likely. Enjoy your new athletic level.

You’ll have to decide whether to tell your competitive friends!

Transfer Factor Ultra

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Improve your athletic ability

Transfer Factor Ultra: CortControl Immune System Enhancement

Glutrasol Dietary Supplement

CortControl develops and markets patented specialty nutraceuticals

CortControl develops and markets Transfer Factor Ultra and Glutrasol. These patented specialty nutraceuticals support fertility, immune health, and other health concerns.