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Biochemistry of Transfer Factor: Technical Paper

Biochemistry of Transfer Factor. Female scientist looking under microscope doing analysis of test sample.

I. Introduction

Glutrasol and Transfer Factor Ultra products are comprised of three main ingredients:

  1. Transfer Factor: A transfer factor is a chemical taken from a human or animal that has already developed protection (immunity) against a certain disease.
  2. Glucans: A glucan is a polysaccharide derived from D-glucose, linked by glycosidic bonds. Glucans are noted in two forms: alpha-glucans and beta-glucans.
  3. Lactic Acid-generating Bacteria: Lactic acid bacteria are a group of Gram-positive bacteria, non-respiring, non-spore-forming cocci or rods, that produce lactic acid as the primary end product of the fermentation of carbohydrates.

This disclosure focuses on the Biochemistry Transfer Factor. 

Glutrasol and Transfer Factor Ultra work because TEST groups repeatedly show dramatic improvement relative to CONTROL groups.

Here is information on how (biochemically) they work.

II. Inducer/Suppressor Fraction of Transfer Factor

T-lymphocytes produce transfer factors and can transfer the ability to recognize a pathogen to cells that have not been in contact with the pathogen. They also heighten the immune system’s ability to react (increased reactivity or inducer function) to pathogens. Transfer factor produces a trigger for T-cell recognition of antigen.

The transfer factor is a mixture of peptides, typically with a molecular weight < 10,000 Daltons. It’s more appropriate to speak of “transfer factors” instead of “transfer factor.” Fortunately, today’s preparative methods produce consistent mixtures, which lead to repeatable responses.

Fractions within the mixture serve different (and sometimes opposite) purposes. Two significant fractions are (1) the inducer fraction and (2) the suppressor fraction [1][2]. Opposing functions were confirmed using the direct Leucocyte Migration Inhibition (LMI) test.

These two fractions are consistent with field observations that the transfer factor balances the immune system.

For example:

  1. The inducer fraction of transfer factor biochemistry links the immune cells with an antigen-binding site, thereby increasing their reactivity to an antigenic stimulus. This is advantageous when a higher immune response is required. CortControl’s enhanced vaccine response arises from an inducer fraction. Several researchers have documented the inducer effects of transfer factors [3][4][5].
  2. The suppressor fraction blocks the response of the T-cells and signals a down-regulation of the immune response. This is helpful in allergic or autoimmune conditions. Animal studies demonstrate improvement in cases where the immune system is over-active. This arises from suppressor fraction. Cortesini R. et al. [6] showed that CD8+CD28-Ts represent a unique subset of regulatory cells within the transfer factor that initiates a suppressive loop. Filaci [7] supported Cortesini’s work and related autoimmune diseases without CD8+ suppressor T lymphocytes. Filaci further found that “CD8+ Ts can be generated in vitro from CD8+CD28-T lymphocytes. A key role in their generation is played by monocytes that secrete interleukin-10 (IL-10) after granulocyte macrophage-colony-stimulating factor (GM-CSF) stimulation.”

Aleli Salazar-Ramiro et al. [8] view cancer as an autoimmune disease and propose a transfer factor for cancer therapy. This is supported by CortControl’s veterinary work on horses, dogs, and cows [9], where cancer symptoms were visibly reversed.

Immune Enhancement Dietary Supplement. Glutrasol™ offers humans therapeutic levels of transfer factors, glucans, prebiotics and probiotics, vitamins, and minerals, and has a rich vanilla flavor.

Glutrasol Dietary Supplement

Glutrasol offers therapeutic levels of transfer factors, glucans, prebiotics and probiotics, vitamins, and minerals and has a rich vanilla flavor.

Learn More

III. TH1/TH2 Helper Cells and Cytokines

Reviewing the helper lymphocyte paradigm helps categorize the transfer factor applications. Helper lymphocytes develop along two cell populations: TH1 and TH2. Transfer factors from both lymphocyte lines are represented in the transfer factor biochemistry. TH1 and TH2 cells perform different functions and produce different cytokines—proteins that function as messenger molecules.

Cell-mediated or TH1 helper responses are essential in the body’s ability to defend itself against viruses, fungi, parasites, cancer, and intracellular organisms. TH1 cells modulate cell-mediated immunity.

TH1 cells produce the following cytokines:  

  • IL-2,  
  • IFN-gamma, and
  • TNF-alpha

TH2 cells modulate humoral immunity (antibody production).

TH2 cells produce the following cytokines:

  • IL-4,
  • IL-5,
  • IL-6,
  • IL-10, and
  • IL-13

Cytokines are functionally similar to hormones but are not associated with a specific gland.

They appear to operate as keys and templates.

  • Cytokines are a broad and loose category of small proteins essential in cell signaling. Due to their size, cytokines cannot cross the lipid bilayer of cells to enter the cytoplasm and, therefore, typically exert their functions by interacting with specific cytokine receptors on the target cell surface.

Stereochemistry is important.

What is stereochemistry in simple terms?

  • A branch of chemistry that deals with the spatial arrangement of atoms and groups in molecules.
  • The spatial arrangement of atoms and groups in a compound and its relation to the properties of the compound.

The attachment of a cytokine to an immune cell receptor starts a specific immune signal within the target cell. Signals translate into direct action, increase the production of antibodies against an invading virus, or initiate the production of other cytokines to propagate the signal.

IV. TH1/TH2 Predominant Phenotypes 

One aspect of immune regulation involves homeostasis between T-helper 1 (Th1) and T-helper 2 (Th2) activity [10]. TH1/TH2 balance correlates with good health, and over-activation in either direction sets the stage for disease.

Th1 and Th2-helper cells direct different immune response pathways and produce different cytokines. Either pathway can down-regulate the other.

Steven Bock, MD, correlated disease conditions to an imbalance of TH1 and TH2. For example, if one has a TH2-dominated condition, the disease conditions that tend to prevail are:

  1. Allergies
  2. Chronic sinusitis
  3. Atopic eczema
  4. Asthma
  5. Systemic autoimmune conditions such as lupus erythematosus and mercury-induced autoimmunity
  6. Vaccination-induced state
  7. Certain cases of autism
  8. Hyperinsulinism
  9. Pertussis vaccination
  10. Malaria
  11. Helminth infection
  12. Hepatitis C
  13. Chronic giardiasis
  14. Hypercortisolism
  15. Chronic candidiasis
  16. Cancer
  17. Viral infections
  18. Ulcerative colitis

If one has a TH1-dominated condition, the conditions that tend to prevail are:

  1. Diabetes type 1
  2. Multiple sclerosis
  3. Rheumatoid arthritis
  4. Uveitis
  5. Crohn’s disease
  6. Hashimoto’s disease
  7. Sjögren’s syndrome
  8. Psoriasis
  9. Sarcoidosis
  10. Chronic Lyme disease
  11. H. pylori infections
  12. E. histolytica

Glutrasol field observations show successes in both categories. For example, international travelers avoid flu and colds by consuming Glutrasol before a trip. In addition, Ramaekers Nutrition has success with psoriasis, Crohn’s disease, and H pylori infections (among a 20-year list of others). The biochemistry of transfer factor in Glutrasol contains cytokines from both TH1 and TH2 cells. It produces different cytokines for different situations.

Alvarez-Thull L, Kirkpatrick CH [11] note that “Transfer factor treatment selectively affects cytokine production in response to antigenic stimulation.”

Fabre RA et al. [12] (in a pulmonary tuberculosis study) showed that “the treatment with murine or human TF [transfer factor] restored the expression of TH-1 cytokines, TNFalpha and iNOS, provoking inhibition of bacterial proliferation and significant increase of DTH and survival.”

Transfer Factor Ultra. Mushroom Extract. Proprietary Blend. Immune Enhancement through Cytokine Balance.

Transfer Factor Ultra

Transfer Factor Ultra ingredients are formulated at therapeutic levels for severe illness or as prevention for significant health challenges. As with any supplement, it is advisable to seek advice from your healthcare professional to ensure it suits you.

Learn More

V. Adjusting to Change

Malaria is cited as a TH2-dominated condition WHO [13] and PATH are working on a robust malaria vaccine.

CortControl acknowledges that parasites can mutate [14] and present a changing appearance to the immune system. This is one reason for the cyclical flare-ups experienced by malaria victims. Antibody vaccines are specific and not designed to keep pace with mutations.

Maturation time for TH1 or TH2 cells is 10-14 days. In contrast, the biochemistry of transfer factor works on the innate immune system and responds within 24-48 hours. Transfer factor empowers the immune system to stay current with mutations.

CortControl predicts that the immediate benefits of combining Glutrasol with malaria vaccine will be:

  1. Increasing vaccine efficiency and
  2. Minimizing relapse or re-infection.

VI. Rebalancing TH1 and TH2 Levels

Transfer factor can change TH1/TH2 predominance conditions within 48 hours [15].

This observation asks, “How can Transfer Factor change a predominantly TH-2 Immune System to a predominant TH-1 System so rapidly?”*

*The hypothesis of new TH1 cells was dismissed early because it takes 10-14 days to mature new TH1 cells.

The answer is “conversion by eomesodermin,” which was studied [16] in 2003.

  • Eomesodermin. Also known as T-box brain protein 2, is a protein encoded by the EOMES gene in humans. The Eomesodermin/Tbr2 gene, EOMES, encodes a member of a conserved protein family that shares a common DNA-binding domain, the T-box.

In that study, already-differentiated TH2 cells were converted to TH1 cells. Eomesodermin is a T-box transcription factor related to T-bet and is already characterized as a key regulator of mesodermal differentiation. Eomesodermin was up-regulated explicitly in activated CD8+ cells [one of the transfer factor’s actions].

The conversion of TH2 to TH1 cells applies to viral vaccines and malaria, which tend to be TH2-dominated. In the opposite direction, the conversion of TH1 to TH2 is advantageous for Rheumatoid arthritis or Crohn’s disease.

VII. Viruses, Bacteria, and Parasites

Web MD notes, “Transfer factors are used for infectious conditions in people with weak immune systems. These infectious conditions include bacteria or viruses in the bloodstream (septicemia), sinus infections, bronchitis, influenza, swine flu, the common cold, shingles, chickenpox, hepatitis B, fungal infections such as coccidioidomycosis, yeast infections (candidiasis), parasitic infections such as leishmaniasis and cryptosporidiosis, and leprosy.

Transfer factors are also used against infections caused by viruses such as cytomegalovirus (CMV) and Epstein-Barr virus, bacteria such as Mycobacterium tuberculosis, Mycobacterium fortuitum, and Mycobacterium avium, and yeast-like fungi such as Cryptococcus and Pneumocystis carinii.

The Glutrasol formulation dramatically lowered the mortality rate of parasite-infected livestock herds [9]. Simultaneously, weight gain improved.

CortControl does not believe that we “cured” the affected herds. Instead, we believe Glutrasol better staged the subject’s immune system to resist parasites and opportunistic infections.

This immune response has applications for countries where water-borne parasites negatively affect child development.

Stunted childhood growth is a significant global health issue. Low weight gain in livestock and stunted human growth are probably related.

VIII. Staging the Immune System

The response to vaccination depends on the recipient’s health. Vaccines work best for healthy people. Conversely, a person with a weakened immune system may not receive the calculated vaccine benefits. This relationship is significant in less developed countries, where unsanitary conditions impact overall health.

Dr Mandal [17] notes, “This [a lower-than-expected vaccine response] could be due to various reasons. Sometimes, this is because the host’s immune system doesn’t respond adequately or at all. This could be in diseased persons with lowered immunity, e.g., in people with diabetes, those on steroids or other immunity-suppressing drugs, or those with HIV infection.

B-Cell Activation. Once B cells are activated, they become plasma cells that produce antibodies in response to an antigen. They can also become memory cells that remember the antigen so the immune system can quickly identify and fight it in the future.

The non-development of immunity to disease could also be because the host’s immune system does not have a B cell capable of generating antibodies against the antigen or microbe or the immune system may not be strong enough to fight off the infection”.

Glutrasol. Formulated to narrow the health gap and make vaccine benefits accessible to a larger population.

IX. Adjuvant Application

Several articles suggest the use of the Transfer Factor as an adjuvant.

  • An adjuvant is a chemical substance added to some vaccines to help the body’s immune system respond more effectively to the vaccine’s antigens.

Schroder et al. [18] state, “This interspecies adjuvant effect was proportional to the dose of the ‘transfer-factor’ preparations administered, depended on the method of their preparation, and was expressed in the administration of the preparations simultaneously with the immunization.”

Wang et al. [19] state, “In conclusion, these results suggest that TF [transfer factor] possess better cellular immune-enhancing capability and would be exploited into an effective immune-adjuvant for inactivated vaccines.”

X. Dramatic Pictures of Results of Consuming Transfer Factor

The following images are two patient examples. We have an extensive database of animal results using our patented formulas.

Calf with Severe Warts

Before Transfer Factor Consumption

Before Transfer Factor Consumption. Cow with severe warts.

6 Months Later

After Transfer Factor Consumption

After Transfer Factor Consumption. Cow with severe warts.

Horse with Eye Cancer

Before Transfer Factor Consumption

Before Transfer Factor Consumption. Horse with eye cancer. Image one.

During Transfer Factor Consumption

During Transfer Factor Consumption. Horse with eye cancer. Image two.

After Transfer Factor Consumption

After Transfer Factor Consumption. Horse with eye cancer.

References

  1. Lawrence HS, Borkowsky W., “Transfer factor—current status and future prospects,” Biotherapy 1996;9(1-3):1-5. https://www.ncbi.nlm.nih.gov/pubmed/8993750
  2. www.linked2.info/dvm
  3. Mazaheri R, Hamblin AS, Zuckerman AJ., “Cell-mediated immunity: correlation of mixed-leucocyte-macrophage migration inhibition with delayed-type hypersensitivity after immunization and donor-specific transfer of cell migration inhibition by dialyzable leucocyte extract,” Cell Immunol. 1983 Nov;82(1):147-62. https://www.ncbi.nlm.nih.gov/pubmed/6196129
  4. Kirkpatrick CH, Rich RR, Smith TK., “Effect of transfer factor on lymphocyte function in anergic patients,” J Clin Invest, 1972 Nov;51(11):2948-58. https://www.ncbi.nlm.nih.gov/pubmed/5080419
  5. Salazar-Ramiro A, Hernández-Pedro NY, Rangel-Lopez E, Cruz VPD, Estrada-Parra S, et al., “Dialyzable Leukocyte Extract (Transfer Factor) as Adjuvant Immunotherapy in the Treatment of Cancer,” MOJ Auto Dis 1(1): 00003. DOI: 10.15406/mojad.2016.01.00003. http://medcraveonline.com/MOJAD/MOJAD-01-00003.php
  6. Cortesini R1, LeMaoult J, Ciubotariu R, Cortesini NS., “CD8+CD28- T suppressor cells and the induction of antigen-specific, antigen-presenting cell-mediated suppression of Th reactivity”, Immunol Rev. 2001 Aug;182:201-6. https://www.ncbi.nlm.nih.gov/pubmed/11722635
  7. Filaci G. et al., “Nonantigen specific CD8+ T suppressor lymphocytes originate from CD8+CD28- T cells and inhibit both T-cell proliferation and CTL function”, Hum Immunol. 2004 Feb;65(2):142-56. https://www.ncbi.nlm.nih.gov/pubmed/14969769
  8. Salazar-Ramiro A, Hernández-Pedro NY, Rangel-Lopez E, Cruz VPD, Estrada-Parra S, et al., “Dialyzable Leukocyte Extract (Transfer Factor) as Adjuvant Immunotherapy in the Treatment of Cancer,” MOJ Auto Dis 1(1): 00003. DOI: 10.15406/mojad.2016.01.00003. http://medcraveonline.com/MOJAD/MOJAD-01-00003.php
  9. http://ramaekersnutrition.com/library/the-mechanism-of-transfer-factor/
  10. Kidd P., “Th1/Th2 balance: the hypothesis, its limitations, and implications for health and disease”, Altern Med Rev. 2003 Aug; 8(3):223-46. https://www.ncbi.nlm.nih.gov/pubmed/12946237
  11. Kirkpatrick CH, Rich RR, Smith TK., “Effect of transfer factor on lymphocyte function in anergic patients,” J Clin Invest, 1972 Nov;51(11):2948-58. https://www.ncbi.nlm.nih.gov/pubmed/5080419
  12. https://www.ncbi.nlm.nih.gov/pubmed/15086383
  13. http://www.who.int/mediacentre/factsheets/fs094/en/ “Malaria Fact sheet N 94”. WHO. March 2014.
  14. http://www.theexpandedheart.com/Transfer.html
  15. http://ramaekersnutrition.com/library/the-mechanism-of-transfer-factor/
  16. SCIENCE, p. 1041, Vol. 302, Nov. 2003. http://science.sciencemag.org/content/302/5647
  17. http://www.news-medical.net/health/Vaccine-Effectiveness.aspx
  18. https://www.ncbi.nlm.nih.gov/pubmed/419903
  19. www.ncbi.nlm.nih.gov/pubmed/22705080

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Specialty Nutraceuticals and Fertility

Specialty Nutraceuticals and Fertility. Doctors and nutritionists can now offer patients a valuable comprehensive fertility support program.

Supporting fertility in more people

For years, a significant barrier for couples seeking fertility support has been—purely and simply—cost. One recent University of California, San Francisco (UCSF) study revealed that couples seeking the popular treatment, in vitro fertilization (IVF), have an average out-of-pocket expense of $19,234.

In the U.S., this comes to an average of 44% of the annual disposable income for couples seeking treatment. “For many patients,” UCSF infertility specialist James F. Smith, MD, has noted, “the high costs … represent a significant burden on household finances and almost certainly have a major role in fertility treatment decision making.” 

The specialty nutraceutical option 

However, recent developments in specialty nutraceuticals may provide doctors and nutritionists with a valuable new option for offering their patients the solid first step in a comprehensive fertility support program.

These nutraceuticals also provide pharmaceutical companies focused on fertility support new opportunities to expand their product portfolios and their total available market. Considering the “significant” cost burden of traditional treatments for many couples and the chance to develop the total treatment market, the right nutraceutical is undoubtedly an option more doctors and pharmaceutical companies might want to investigate.

Specialty nutraceuticals and fertility treatment

Why specialty nutraceuticals?

While there is still some skepticism about specialty nutraceuticals, a growing body of evidence suggests that, as well as being far less costly than traditional fertility drugs and treatments, they may also be—in some instances—more effective.

To learn more, check out the Dietary Supplements Guidance Documents and Regulatory Information page on the FDA’s website.

CortControl’s specialty nutraceuticals

At CortControl, for example, we have a specialty nutraceutical called Glutrasol and Transfer Factor Ultra. For more than 20 years, veterinarians have prescribed many of its essential compounds to treat diseases and conditions in mammals, and the success of these treatments is well-documented and quite dramatic. In some cases, for example, fertility in cattle increased by more than 70%.  

Immune Enhancement Dietary Supplement. Glutrasol™ offers humans therapeutic levels of transfer factors, glucans, prebiotics and probiotics, vitamins, and minerals, and has a rich vanilla flavor.

Glutrasol Dietary Supplement

Glutrasol offers therapeutic levels of transfer factors, glucans, prebiotics and probiotics, vitamins, and minerals and has a rich vanilla flavor.

Learn More

Why are we confident our supplements will make a difference in humans?

The answer is in science. All mammals, humans included, have essentially the exact cortisol production mechanism, and when the body produces too much cortisol, the chances of becoming infertile can increase in some instances.

Controlling cortisol production

Designed to control high cortisol production levels, Glutrasol and Transfer Factor Ultra—much like the compounds veterinarians have prescribed to cattle for years to increase fertility—should (and we believe will) have a similar effect on humans.

Cortisol Stress Hormone. Scale showing elevated stress level.

Cortisol is a stress hormone that can affect fertility in both men and women. 

When women are stressed, the brain produces cortisol, which can disrupt the ovaries’ function and the release of eggs.

  • Hormonal balance: Cortisol can disrupt the hormonal balance needed to mature eggs. It can also decrease estradiol, which can damage egg quality.
  • Ovulation: Cortisol can disrupt signaling between the brain and ovaries, delaying or preventing ovulation.
  • Menstrual cycle: High levels of cortisol and prolactin can impair the menstrual cycle.
  • Blood flow: Cortisol can reduce blood flow to reproductive organs, like the ovaries.

Cortisol can also suppress reproductive hormones, leading to abnormal ovulation, anovulation, and amenorrhea.

  • Ovulation is when an ovary releases an egg that can be fertilized by sperm, potentially leading to pregnancy.
  • Anovulation, also known as an anovulatory cycle, is a medical condition that occurs when an egg is not released from the ovaries during a menstrual cycle.
  • Amenorrhea is when a woman who usually menstruates doesn’t have a period for three months or more if she’s had regular cycles or six months or more if she’s had at least one spontaneous period before.

The stress hormone cortisol affects fertility in men. 

Cortisol can impact sperm production and motility in men. FSH, which is secreted by the anterior pituitary in response to GnRH, stimulates sperm production. 

  • In men, Follicle-stimulating hormone (FSH) helps control the amount of sperm that the testicles (testes) make and affects the health of the sperm.
  • The gonadotropin-releasing hormone (GnRH) causes the testicles to produce testosterone.

Stress can also lead to behavioral changes that can impact fertility, such as decreased sex drive and motivation. While occasional stress may not affect fertility, chronic stress can lead to hormone imbalances that make it difficult to conceive.

What is the role of nutraceuticals in fertility?

Currently, nutraceuticals are a common and popular way to mitigate the male fertility issues of pre-testicular, testicular, and post-testicular etiologies.

  • Pre-testicular etiologies, also known as extra-gonadal endocrine disorders, are fertility issues that originate outside the reproductive system and prevent the testes from receiving adequate support. These disorders can affect spermatogenesis and originate in the hypothalamus, pituitary, or adrenals.
  • Testicular etiologies may derive from varicocele-induced testicular damage, undescended testes, testicular torsion, mumps orchitis, gonadotoxic effects from medications (including chemotherapy, radiation, and surgical resection), genetic abnormalities, and idiopathic causes (any disease that is of uncertain or unknown origin may be termed idiopathic).
  • Post-testicular etiologies are causes of infertility that occur after the testes and primarily involve obstructions in the ducts that lead away from the testes. These obstructions can occur anywhere in the male reproductive tract.

Nutraceuticals possess multi-nutritional factors that improve metabolic activity, regulating hormonal profile and sperm production.

Transfer Factor Ultra. Mushroom Extract. Proprietary Blend. Immune Enhancement through Cytokine Balance.

Transfer Factor Ultra

Transfer Factor Ultra ingredients are formulated at therapeutic levels for severe illness or as prevention for significant health challenges. As with any supplement, it is advisable to seek advice from your healthcare professional to ensure it suits you.

Learn More

Nutrition plays a crucial role in fertility.

If you continuously supply your body with supplements, they can impact your metabolism, hormones, and entire endocrine system, which regulates fertility.

Eating a healthy, well-balanced diet and taking the proper supplements can improve fertility for both men and women.

Eating a healthy, will-balanced diet and taking the proper supplements can improve fertility for both men and women.

It is worth a close look

We are not claiming that specialty nutraceuticals such as Glutrasol and Transfer Factor Ultra are silver bullets. We are saying, however, that they offer promise in supporting fertility for a relatively low cost AND that they are worth considering as part of a comprehensive fertility support strategy—one that will ultimately enable more people to take advantage of infertility treatments.

A new approach to supporting fertility

Glutrasol and Transfer Factor Ultra are unique and patented science-based specialty supplements that offer a new approach to supporting fertility. They’re designed to address compromised immune function due to elevated stress, a factor that may contribute to an estimated 30% of all fertility problems in both women and men.

Consider enhancing your fertility with Glutrasol and Transfer Factor Ultra if you are:

  • Couples with fertility issues
  • Have known stressors that may be inhibiting fertility
  • Could benefit from minimizing the impact stress is having on your fertility
  • Looking for a natural, non-invasive, less costly fertility aid to enhance your ability to conceive

Specific positive outcomes include:

  • Significant increase in egg health 
  • Increase in the number of healthy eggs 
  • Increase in sperm count

CortControl develops, and markets patented specialty nutraceuticals

CortControl develops and markets Glutrasol and Transfer Factor Ultra. These patented specialty nutraceuticals support fertility, immune health, and other health concerns.

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Medical Foods: As Patients Consider New Personalized Treatment Options, Health Care Providers Should Too

Medical Foods: As patients consider new personalized treatment options, healthcare providers should too. Integrative medicine offers options.

Like everything dynamic, healthcare treatment is evolving rapidly.

Today, more and more consumers are becoming intrigued by an approach to health care called “integrative medicine,” which offers new options—and opportunities—for improved personalized treatment for patients.

Furthermore, integrative medicine is not something radically new or different. The premise behind it is about as basic and sensible as ideas come. The thinking is that the best healthcare solutions might not necessarily be one-dimensional, as in “take this pill three times a day.” Instead, it might be a combination of drugs and complementary remedies such as diet, exercise, vitamins, and FDA-accepted specialty nutraceuticals. 

What is a specialty nutraceutical? 

Specialty nutraceuticals are dietary products explicitly developed to support specific structures or physical functions in the body. The term is a broad umbrella term used to describe any product derived from food sources that offers extra health benefits in addition to the basic nutritional value found in foods.

Of course, for some, the term “specialty nutraceutical” does not sound familiar, like “exercise” or “vitamins.”  These nutraceuticals are still unfamiliar even to many doctors and others in health care.

Nutraceuticals are not substitutes for drugs and other traditional medical treatments but rather part of this integrative approach to safely and effectively support health issues.

Difference between a nutraceutical and a medicine

What is the difference between a nutraceutical and a medicine?

For one thing, pharmaceuticals are FDA-approved drugs designed to treat diseases and provide immediate relief. In contrast, nutraceuticals are nutrient-rich dietary substances derived from whole food or parts of food sources, offering health benefits beyond essential nutrition.

To learn more, check out the Dietary Supplements Guidance Documents and Regulatory Information page on the FDA’s website.

Doctors and pharmaceutical companies are slow to adapt 

While interest in specialty nutraceuticals grows among consumers, many doctors and pharmaceutical companies resist them.

In one recent American Hospital Association survey, for example, 44% of respondents listed “physician resistance” as one of the three main barriers to adopting integrative medicine programs that may include specialty nutraceuticals in the mix.

Further barriers include some pharmaceutical companies. Instead of looking at nutraceuticals as an opportunity to serve their customers and pursue a potential revenue opportunity, they see specialty supplements as a threat to their businesses rather than a potential revenue opportunity to explore.

This pharma resistance is a shame because specialty nutraceuticals represent a promising new option for doctors and patients and a significant market opportunity for these companies.

It’s a slow process, but specialty nutraceutical markets are expected to grow in the next few years, providing patients with more solutions and treatment options.

Immune Enhancement Dietary Supplement. Glutrasol™ offers humans therapeutic levels of transfer factors, glucans, prebiotics and probiotics, vitamins, and minerals, and has a rich vanilla flavor.

Glutrasol Dietary Supplement

Glutrasol offers therapeutic levels of transfer factors, glucans, prebiotics and probiotics, vitamins, and minerals and has a rich vanilla flavor.

Learn More

Pharma, food, and nutraceuticals

Nutraceuticals are positioned between food and pharmaceuticals and are comprised of foods and substances—or combinations of substances—consisting of molecules or elements found in nature used to maintain or improve health and treat or prevent diseases and conditions.

To benefit consumers, pharmaceutical companies can:

  • Acknowledge the growing consumer interest in, and become advocates for, personalized treatment.
  • View specialty nutraceuticals as enhancements to their product lines and a clear competitive edge.
  • License patented, FDA-accepted specialty supplements to manufacture and distribute to their core markets. (Because these foods are already FDA-accepted, R&D costs are minimal, and time to market is rapid.)
  • Manufacture and offer products with substantial profit margins.
  • Help physicians and clinics improve their treatment protocols and better differentiate themselves. 
Transfer Factor Ultra. Mushroom Extract. Proprietary Blend. Immune Enhancement through Cytokine Balance.

Transfer Factor Ultra

Transfer Factor Ultra ingredients are formulated at therapeutic levels for severe illness or as prevention for significant health challenges. As with any supplement, it is advisable to seek advice from your healthcare professional to ensure it suits you.

Learn More

Personalized treatment is an idea whose time has come.

Medical foods are integral to this new standard, perspective, and set of ideas. This new paradigm is a new way for big pharma companies to reach customers and drive profits. Responding to this growing consumer demand makes sense for doctors who want to provide new patient options and pharmaceutical companies who want to strengthen their competitive edge.

Transfer Factor Ultra: CortControl Immune System Enhancement

If you’re looking for a dietary supplement that can help strengthen your immune system, Transfer Factor Ultra can be a viable option. This supplement contains Transfer Factor (TF), which helps educate and improve the immune system’s defense against harmful pathogens.

Glutrasol Dietary Supplement

Glutrasol provides an extra defense against the flu and other seasonal illnesses. It’s also excellent when traveling because it helps you avoid exposure to travel-related diseases. Gultrasol helps strengthen your overall immune health, especially if you are susceptible to disease or are elderly, not to mention if you spend time around many people, especially if they are sick.

CortControl develops, and markets patented specialty nutraceuticals

CortControl develops and markets Transfer Factor Ultra and Glutrasol. These patented specialty nutraceuticals support fertility, immune health, and other health concerns.

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Improve Your Athletic Ability: 2024 Specialty Nutraceuticals

Improve Your Athletic Ability with Specialty Nutraceuticals.

Improve Your Athletic Ability

Athletes, are you interested in performing at a higher level at your next athletic event? Are you looking for a better time, distance, more scored goals, or easier recovery after the event? We guess “absolutely” because sporting enjoyment and ability are two parts of the same package. 

You may be an extreme athlete competing in every Ironman you can or an enthusiastic athlete who exercises hard but focuses more on physical enjoyment. Either way (extreme or energetic), modern athletes are learning that your immune system affects your athletic ability. The power of the immune system is not limited to wellness versus illness. 

Extreme Athletes 

If you are an extreme athlete, you understand first-hand the physical impacts of training, sleep, performance, and recovery. It’s not always pleasant. 

Before an event, mental stress depletes energy reserves and reduces sleep quality. In turn, poor sleep detracts from performance. After an event, recovery takes time, and you are susceptible to getting sick for roughly five days. 

Enthusiastic Athletes

If you are an enthusiastic athlete, your internal experience differs. Moderate levels of exercise are beneficial for the immune system. But your performance could be better. 

Difference between extreme and enthusiastic athletes summarized

Bente Klarlund Pedersen and Anders Dyhr Toft (Copenhagen Muscle Research Centre and Department of Infectious Diseases) summarize this difference between extreme and enthusiastic athletes.

They state, “Moderate exercise across the lifespan seems to increase resistance to upper respiratory tract infections, whereas repeated strenuous exercise suppresses immune function.”* 

*“Effects of exercise on lymphocytes and cytokines.”

The solution for extreme and enthusiastic athletes is to build and improve the immune system. 

To start, here are some basics. 

  • Your immune system has immune cells and immune proteins (technically called cytokines). Immune cells include macrophages (“big eaters”). As implied, the “big eaters” protect us by literally consuming viruses, fungi, and bacteria. 
  • Immune proteins are the bosses of the immune system. They direct the action. Immune proteins work best when balanced. The imbalance isn’t good.
  • Immune proteins also connect the immune system to the central nervous system. These immune proteins facilitate the release of regulating hormones, which mediate various everyday performance issues. 
  • Particularly important is that immune proteins can be increased and balanced.
Immune Enhancement Dietary Supplement. Glutrasol™ offers humans therapeutic levels of transfer factors, glucans, prebiotics and probiotics, vitamins, and minerals, and has a rich vanilla flavor.

Glutrasol Dietary Supplement

Glutrasol offers therapeutic levels of transfer factors, glucans, prebiotics and probiotics, vitamins, and minerals and has a rich vanilla flavor.

Learn More

Balancing the immune proteins is a powerful way to build the immune system.

Diet alone may not provide the immune proteins needed for balance. Enter Glutrasol. This performance supplement enhances immune protein balance in two ways.

First, balanced cytokines are injected directly into the digestive tract (where they are stable) and enter the body through the intestinal wall. 

Second, even more balanced cytokines are produced within the body. That means that missing immune proteins are replaced. 

Improve your athletic ability with specialty nutraceuticals.

Performance increases can be dramatic for all athletes because immune protein balance is restored. Energy levels increase, and a feeling of wellness arises.

Stamina replaces endurance. Motivation is easy when you feel good. For extreme athletes, recovery is fast, and respiratory infections are less likely. Enjoy your new athletic level.

You’ll have to decide whether to tell your competitive friends!

Transfer Factor Ultra. Mushroom Extract. Proprietary Blend. Immune Enhancement through Cytokine Balance.

Transfer Factor Ultra

Transfer Factor Ultra ingredients are formulated at therapeutic levels for severe illness or as prevention for significant health challenges. As with any supplement, it is advisable to seek advice from your healthcare professional to ensure it suits you.

Learn More

Improve your athletic ability

Transfer Factor Ultra: CortControl Immune System Enhancement

If you’re looking for a dietary supplement that can help strengthen your immune system, Transfer Factor Ultra can be a viable option. This supplement contains Transfer Factor (TF), which helps educate and improve the immune system’s defense against harmful pathogens.

Glutrasol Dietary Supplement

Glutrasol provides an extra defense against the flu and other seasonal illnesses. It’s also excellent when traveling because it helps you avoid exposure to travel-related diseases. Gultrasol helps strengthen your overall immune health, especially if you are susceptible to disease or are elderly, not to mention if you spend time around many people, especially if they are sick.

CortControl develops and markets patented specialty nutraceuticals

CortControl develops and markets Transfer Factor Ultra and Glutrasol. These patented specialty nutraceuticals support fertility, immune health, and other health concerns.

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Integrative Medicine: Solid Evidence Is Key

Integrative Medicine. Robotic arm in lab adjusting components autonomously.

Integrative Medicine: Solid Evidence Is Key

Integrative Medicine is an approach to medical care that recognizes the benefit of combining conventional (standard) therapies (such as drugs and surgery) with complementary therapies (such as acupuncture, yoga, and specialty nutraceuticals) that are safe and effective.

In recent years, we’ve heard more and more about “integrative medicine,” a treatment approach that combines traditional medicines and evidence-supported alternative remedies to treat the whole person, not just a disease. 

Integrative medicine can help you develop a robust immune system

Integrative medicine is known as “holistic medicine,” “complementary medicine,” or “complementary and alternative medicine” (CAM). Once considered “fringe,” this approach has quickly entered the medical mainstream. 

Solid evidence is the critical component of Integrative Medicine

The American Hospital Association surveys show that the number of U.S. hospitals offering complementary therapies has grown dramatically, from 9% in 1998 to 42% in 2011. 

Academic Health Centers

More than 60 academic and professional medical centers in the U.S., Canada, and Mexico have formed the Consortium of Academic Health Centers for Integrative Medicine to promote integrative medicine throughout North America. These centers include Harvard, Yale, Stanford, Duke, USC, and the University of Michigan. 

Doctors’ Lingering Doubts

Integrative medicine is practiced more widely than ever, but many doctors continue to have lingering concerns about it. In one hospital survey, for example, 44% of respondents listed “physician resistance” as one of the three main barriers to adopting integrative medicine programs.

Numerous doctors cite the lack of scientific evidence for their hesitation. “I worry that people are making claims in the context of scientific medicine that they cannot really justify,” Dr. Tom Delbanco of Harvard Medical School has stated. “There have been few rigorously controlled, scientifically sound studies in the area.”

Immune Enhancement Dietary Supplement. Glutrasol™ offers humans therapeutic levels of transfer factors, glucans, prebiotics and probiotics, vitamins, and minerals, and has a rich vanilla flavor.

Glutrasol Dietary Supplement

Glutrasol offers therapeutic levels of transfer factors, glucans, prebiotics and probiotics, vitamins, and minerals and has a rich vanilla flavor.

Learn More

Solid Evidence Is the Critical Component

Regardless of how different doctors view integrative medicine, virtually all agree on the importance of meticulous scientific research and solid evidence: 

  • Was the testing controlled and double-blind?
  • Was the sample group representative? 
  • Were biases built into the test procedure? 
  • Were the conclusions appropriately drawn from the data and not overstated? 
  • If a mean result is stated, what is the confidence interval for that mean? 
  • What is the probability that a difference is due to chance? 

It’s reasonable to ask such questions, and when there is a compelling scientific basis for a particular integrative therapy, doctors will consider it.

Unfortunately, much of the discussion on integrative therapies thus far has focused on treatments such as herbs or meditation, where there is often little or no hard evidence to substantiate claims of effectiveness.

Considering the Specialty Nutraceuticals Option

Doctors who demand evidence also have another option: the integrated category of specialty supplements. Still unfamiliar to many in health care, these are dietary products developed to support specific structures and physical functions. They are not substitutes for drugs and other traditional medical treatments but rather part of an integrative medical approach that safely and effectively addresses diseases and other conditions. 

Transfer Factor Ultra. Mushroom Extract. Proprietary Blend. Immune Enhancement through Cytokine Balance.

Transfer Factor Ultra

Transfer Factor Ultra ingredients are formulated at therapeutic levels for severe illness or as prevention for significant health challenges. As with any supplement, it is advisable to seek advice from your healthcare professional to ensure it suits you.

Learn More

Learn More

To learn more about medical foods, visit the FDA’s Dietary Supplements Guidance Documents and Regulatory Information.

Health & Wellness

Although it is quickly coming into the medical mainstream, integrative medicine is still a relatively new treatment approach. As such, it offers both great promise and reason for skepticism. The challenge, of course, is to separate the effective options from the ineffective or even harmful ones.

The best place to start this process is to look at those options that have proven their value and gained FDA acceptance.

CortControl develops and markets patented specialty nutraceuticals

CortControl develops and markets Transfer Factor Ultra and Glutrasol. These patented specialty nutraceuticals support fertility, immune health, and other health concerns.

CONNECT WITH US